Neurobiology of Disease Parkinsonian Beta Oscillations in the External Globus Pallidus and Their Relationship with Subthalamic Nucleus Activity
نویسندگان
چکیده
Nicolas Mallet,1,2* Alek Pogosyan,2 László F. Márton,1,3 J. Paul Bolam,1 Peter Brown,2 and Peter J. Magill1* 1Medical Research Council Anatomical Neuropharmacology Unit, University of Oxford, Oxford OX1 3TH, United Kingdom, 2Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London WC1N 3BG, United Kingdom, and 3Neural Systems Research Group, Sapientia– Hungarian University of Transylvania, 540485 Târgu-Mureş, Romania
منابع مشابه
Neurobiology of Disease Conditions for the Generation of Beta Oscillations in the Subthalamic Nucleus–Globus Pallidus Network
The advance of Parkinson’s disease is associated with the existence of abnormal oscillations within the basal ganglia with frequencies in the beta band (13–30 Hz). While the origin of these oscillations remains unknown, there is some evidence suggesting that oscillations observed in the basal ganglia arise due to interactions of two nuclei: the subthalamic nucleus (STN) and the globus pallidus ...
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متن کاملParkinsonian beta oscillations in the external globus pallidus and their relationship with subthalamic nucleus activity.
Inappropriately synchronized beta (beta) oscillations (15-30 Hz) in the subthalamic nucleus (STN) accompany movement difficulties in idiopathic Parkinson's disease (PD). The cellular and network substrates underlying these exaggerated beta oscillations are unknown but activity in the external globus pallidus (GP), which forms a candidate pacemaker network with STN, might be of particular import...
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Hypokinetic symptoms of Parkinson's disease are usually associated with excessively strong oscillations and synchrony in the beta frequency band. The origin of this synchronized oscillatory dynamics is being debated. Cortical circuits may be a critical source of excessive beta in Parkinson's disease. However, subthalamo-pallidal circuits were also suggested to be a substantial component in gene...
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تاریخ انتشار 2008